Preclinical radiation therapy trials conducted on animal models are essential for evaluating the efficacy of new treatments. These trials also help identify and mitigate potential risks, thereby protecting patients from unnecessary harm. However, the process of preclinical radiation therapy trials has long faced industry-wide challenges, especially the inability to accurately identify and locate tumor targets and precisely assess treatment efficacy.
X-ray irradiator is a key device for conducting small animal preclinical trials. Its performance and precision levels determine the reliability of preclinical trial results. Therefore, there is an urgent need for X-ray irradiator with higher precision.
The SHARP 1000, independently developed by Raycision, is a revolutionary multimodality image (CT and optical molecular imaging) guided radiation system for small animals. This technology represents a significant breakthrough in the fields of medical imaging and radiation therapy, effectively addressing the challenges of target identification, localization precision, and efficacy assessment that cannot be resolved by single-modality image-guided treatments. It provides an integrated solution for precise diagnosis, accurate treatment, and precise evaluation.
1. Micro-CT imaging
The micro-CT imaging module of the SHARP 1000 allows for high-quality CT images of mice with an image resolution of 50μm. Advanced GPU-accelerated reconstruction algorithms enable fast and accurate image reconstruction. The micro-CT imaging module provides detailed visualization of the fine structures of tissues, organs, and lesions within the mice, offering rich anatomical information for subsequent research.
2. Molecular imaging
The multimodality imaging function of the SHARP 1000 demonstrates exceptional performance, with a 3D optical molecular imaging resolution of up to 0.2mm. This allows for precise capture of critical information such as the morphology, depth, and signal intensity of small targets within small animals. By using high-precision image registration, the system efficiently integrates the functional information provided by optical imaging with the structural information presented by micro-CT. The seamless integration of structural and functional data provides critical information for in-depth research.
3. Radiotherapy treatment planning
The SHARP 1000 software features an AI-powered contouring algorithm that can automatically and accurately contour the organs of a mouse within 5 seconds. This innovative technology significantly simplifies the previously cumbersome and time-consuming organ contouring process. The radiotherapy treatment planning assists users in completing the entire process of IMRT (Intensity-Modulated Radiation Therapy) including treatment planning, dose calculation, and plan evaluation. The SHARP 1000 employs a GPU-accelerated Monte Carlo dose calculation algorithm, which ensures high precision while achieving unprecedented computational efficiency. This algorithm can complete the entire dose calculation for a mouse radiotherapy plan in just 5 seconds, representing an efficiency improvement of over a thousand times compared to traditional Monte Carlo algorithms.
4. Treatment plan assessment
After completion of the dose calculation, users can conduct 2D dose assessment to evaluate the dose distribution in the axial, coronal, and sagittal planes of mouse. Moreover, a DVH (dose-volume histogram) can be generated to assist a more comprehensive 3D dose assessment of the plan. Once the treatment plan is confirmed, it is loaded into the treatment module, enabling precise irradiation of the targets within the mouse. The entire process ensures the scientific rigor and effectiveness of the radiotherapy.
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